BAIT
KCNMA1
5730414M22Rik, BKCa, MaxiK, Slo, Slo1, mSlo, mSlo1, RP24-486D21.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
GO Process (33)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- adult walking behavior [IMP]
- auditory receptor cell differentiation [IMP]
- cell maturation [IMP]
- cellular potassium ion homeostasis [ISO]
- circadian rhythm [IMP]
- eye blink reflex [IMP]
- locomotor rhythm [IMP]
- micturition [IMP, ISO]
- negative regulation of cell volume [IMP, ISO]
- neuromuscular process controlling balance [IMP]
- neuronal action potential [IMP]
- positive regulation of apoptotic process [ISO]
- potassium ion transmembrane transport [IBA, IGI, ISO]
- potassium ion transport [IDA, ISO]
- protein homooligomerization [IDA]
- protein homotetramerization [ISO]
- regulation of aldosterone metabolic process [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of vasodilation [ISO]
- relaxation of vascular smooth muscle [IMP]
- response to calcium ion [ISO]
- response to carbon monoxide [ISO]
- response to corticosteroid [ISO]
- response to estrogen [ISO]
- response to hypoxia [IDA, ISO]
- response to osmotic stress [ISO]
- response to pH [ISO]
- saliva secretion [IGI]
- sensory perception of sound [IMP]
- smooth muscle contraction involved in micturition [IMP, ISO]
- synaptic transmission [IMP]
- vasodilation [IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- caveola [ISO]
- cell [IMP]
- cytoplasm [IDA]
- dendrite [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IC, IDA, ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone membrane [ISO]
- protein complex [ISO]
- terminal bouton [IDA]
- voltage-gated potassium channel complex [IGI, ISO]
Mus musculus
PREY
CALR
CRT, Calregulin
calreticulin
GO Process (22)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- cell cycle arrest [ISO]
- cellular senescence [IMP, ISO]
- chaperone-mediated protein folding [ISO]
- cortical actin cytoskeleton organization [IDA]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation [ISO]
- peptide antigen assembly with MHC class I protein complex [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of cell cycle [IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein export from nucleus [ISO]
- protein localization to nucleus [IMP, ISO]
- protein stabilization [IDA]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MHC class I peptide loading complex [IMP]
- acrosomal vesicle [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO, ISS]
- endoplasmic reticulum lumen [IDA, ISO]
- external side of plasma membrane [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- polysome [IDA]
- protein complex [ISO]
- sarcoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea.
The large conductance Ca(2+)-activated K(+) or BK channel has a role in sensory/neuronal excitation, intracellular signaling, and metabolism. In the non-mammalian cochlea, the onset of BK during development correlates with increased hearing sensitivity and underlies frequency tuning in non-mammals, whereas its role is less clear in mammalian hearing. To gain insights into BK function in mammals, coimmunoprecipitation and two-dimensional PAGE, ... [more]
Mol. Cell Proteomics Aug. 01, 2009; 8(8);1972-87 [Pubmed: 19423573]
Throughput
- Low Throughput
Curated By
- BioGRID