BAIT
KCNMA1
5730414M22Rik, BKCa, MaxiK, Slo, Slo1, mSlo, mSlo1, RP24-486D21.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
GO Process (33)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- adult walking behavior [IMP]
- auditory receptor cell differentiation [IMP]
- cell maturation [IMP]
- cellular potassium ion homeostasis [ISO]
- circadian rhythm [IMP]
- eye blink reflex [IMP]
- locomotor rhythm [IMP]
- micturition [IMP, ISO]
- negative regulation of cell volume [IMP, ISO]
- neuromuscular process controlling balance [IMP]
- neuronal action potential [IMP]
- positive regulation of apoptotic process [ISO]
- potassium ion transmembrane transport [IBA, IGI, ISO]
- potassium ion transport [IDA, ISO]
- protein homooligomerization [IDA]
- protein homotetramerization [ISO]
- regulation of aldosterone metabolic process [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of vasodilation [ISO]
- relaxation of vascular smooth muscle [IMP]
- response to calcium ion [ISO]
- response to carbon monoxide [ISO]
- response to corticosteroid [ISO]
- response to estrogen [ISO]
- response to hypoxia [IDA, ISO]
- response to osmotic stress [ISO]
- response to pH [ISO]
- saliva secretion [IGI]
- sensory perception of sound [IMP]
- smooth muscle contraction involved in micturition [IMP, ISO]
- synaptic transmission [IMP]
- vasodilation [IMP]
Gene Ontology Molecular Function- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
- actin binding [ISO]
- calcium-activated potassium channel activity [IDA, IGI, IMP, ISO]
- large conductance calcium-activated potassium channel activity [IDA, IMP, ISO]
- potassium channel activity [IGI, IMP]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- voltage-gated potassium channel activity [IDA, IMP, ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- caveola [ISO]
- cell [IMP]
- cytoplasm [IDA]
- dendrite [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IC, IDA, ISO]
- neuronal cell body [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic active zone membrane [ISO]
- protein complex [ISO]
- terminal bouton [IDA]
- voltage-gated potassium channel complex [IGI, ISO]
Mus musculus
PREY
SOD2
MnSOD, Sod-2
superoxide dismutase 2, mitochondrial
GO Process (51)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- age-dependent response to oxidative stress [IMP]
- age-dependent response to reactive oxygen species [ISO]
- apoptotic mitochondrial changes [IMP]
- detection of oxygen [IMP]
- erythrophore differentiation [IMP]
- glutathione metabolic process [IMP]
- heart development [IMP]
- hemopoiesis [IMP]
- hydrogen peroxide biosynthetic process [ISO]
- hydrogen peroxide metabolic process [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- iron ion homeostasis [IMP]
- liver development [IMP]
- locomotory behavior [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- neuron development [IMP]
- oxidation-reduction process [ISO]
- oxygen homeostasis [ISO]
- positive regulation of nitric oxide biosynthetic process [IMP]
- post-embryonic development [IMP]
- protein homooligomerization [ISO]
- protein homotetramerization [ISO]
- regulation of blood pressure [IMP]
- regulation of catalytic activity [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IDA, IMP, ISO]
- respiratory electron transport chain [IMP]
- response to activity [IMP]
- response to axon injury [IMP]
- response to drug [ISO]
- response to gamma radiation [IGI]
- response to hydrogen peroxide [IMP]
- response to hyperoxia [IMP]
- response to nutrient levels [ISO]
- response to oxidative stress [IGI, IMP]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- sensory perception of sound [IMP]
- superoxide anion generation [IMP]
- superoxide metabolic process [IMP, ISO]
- vasodilation [IMP]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea.
The large conductance Ca(2+)-activated K(+) or BK channel has a role in sensory/neuronal excitation, intracellular signaling, and metabolism. In the non-mammalian cochlea, the onset of BK during development correlates with increased hearing sensitivity and underlies frequency tuning in non-mammals, whereas its role is less clear in mammalian hearing. To gain insights into BK function in mammals, coimmunoprecipitation and two-dimensional PAGE, ... [more]
Mol. Cell Proteomics Aug. 01, 2009; 8(8);1972-87 [Pubmed: 19423573]
Throughput
- Low Throughput
Curated By
- BioGRID