MAP3K4
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPK activity [IBA]
- activation of MAPKK activity [ISO]
- chorionic trophoblast cell differentiation [IMP]
- determination of dorsal identity [ISO]
- intracellular signal transduction [IDA]
- male germ-line sex determination [IMP]
- placenta development [IMP]
- positive regulation of JUN kinase activity [IDA, IMP, ISO]
- positive regulation of p38MAPK cascade [ISO]
- protein phosphorylation [ISO]
- regulation of gene expression [IMP]
- response to UV-C [ISO]
Gene Ontology Molecular Function
MAP3K4
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPK activity [IBA]
- activation of MAPKK activity [ISO]
- chorionic trophoblast cell differentiation [IMP]
- determination of dorsal identity [ISO]
- intracellular signal transduction [IDA]
- male germ-line sex determination [IMP]
- placenta development [IMP]
- positive regulation of JUN kinase activity [IDA, IMP, ISO]
- positive regulation of p38MAPK cascade [ISO]
- protein phosphorylation [ISO]
- regulation of gene expression [IMP]
- response to UV-C [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
The MAPK kinase kinase MEKK4 is required for neurulation and skeletal patterning during mouse development. MEKK4 phosphorylates and activates MKK4/MKK7 and MKK3/MKK6 leading to the activation of JNK and p38, respectively. MEKK4 is believed to be auto-inhibited, and its interaction with other proteins controls its dimerization and activation. TRAF4, GADD45, and Axin each bind and activate MEKK4, with TRAF4 and ... [more]
Throughput
- Low Throughput
Additional Notes
- organism unclear
Curated By
- BioGRID