BAIT

NF1

AW494271, E030030H24Rik, Nf-1, RP23-188A3.1
neurofibromatosis 1
GO Process (66)
GO Function (7)
GO Component (10)

Gene Ontology Biological Process

Mus musculus
PREY

BRCA1

RP23-328K2.8
breast cancer 1
GO Process (43)
GO Function (6)
GO Component (13)

Gene Ontology Biological Process

Mus musculus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors.

Maekawa T, Sano Y, Shinagawa T, Rahman Z, Sakuma T, Nomura S, Licht JD, Ishii S

The activating transcription factor, ATF-2, is a target of p38 and JNK that are involved in stress-induced apoptosis. Heterozygous Atf-2 mutant (Atf-2+/-) mice are highly prone to mammary tumors. The apoptosis-regulated gene GADD45alpha and the breast cancer suppressor gene Maspin, both of which are known to be p53 target genes, are downregulated in the mammary tumors arisen in Atf-2+/- mice. ... [more]

Oncogene Feb. 14, 2008; 27(8);1045-54 [Pubmed: 17700520]

Throughput

  • Low Throughput

Curated By

  • BioGRID