SENP1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic signaling pathway [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- post-translational protein modification [TAS]
- protein desumoylation [IMP]
- protein sumoylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SP100
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- chromatin remodeling [IBA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [IC, TAS]
- negative regulation of DNA binding [IDA]
- negative regulation of cellular component movement [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of nucleic acid-templated transcription [IDA]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral transcription [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of Fas signaling pathway [IMP]
- regulation of angiogenesis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to cytokine [IDA]
- response to interferon-gamma [IDA, IMP]
- response to retinoic acid [IDA]
- response to type I interferon [IDA, IMP]
- retinoic acid receptor signaling pathway [IC]
- telomere maintenance [IMP]
- type I interferon signaling pathway [IC]
Gene Ontology Molecular Function- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity (Desumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.
Isopeptidases are essential regulators of protein ubiquitination and sumoylation. However, only two families of SUMO isopeptidases are at present known. Here, we report an activity-based search with the suicide inhibitor haemagglutinin (HA)-SUMO-vinylmethylester that led to the identification of a surprising new SUMO protease, ubiquitin-specific protease-like 1 (USPL1). Indeed, USPL1 neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2G
- desumoylation in vitro
Curated By
- BioGRID