BAIT
RER1
1110060F11Rik, 5830454N22Rik, AU043380, RP23-298E4.2
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
GO Process (4)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CANX
1110069N15Rik, AI988026, Cnx, D11Ertd153e, RP23-237P10.2
calnexin
GO Process (3)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER-mitochondrion membrane contact site [ISO]
- axon [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dendrite cytoplasm [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- integral component of membrane [IDA]
- membrane [IDA, ISO]
- myelin sheath [IDA]
- neuronal cell body [ISO]
- protein complex [ISO]
- ribosome [ISO]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
The Ubiquitin Ligase Synoviolin Up-regulates Amyloid β Production by Targeting a Negative Regulator of γ-Secretase, Rer1, for Degradation.
Alzheimer's disease is characterized by the deposition of Aβ, which is generated from the amyloid precursor protein through its cleavage by β- and γ-secretases. The γ-secretase complex component nicastrin (NCT) plays significant roles in the assembly and proper trafficking of the γ-secretase complex and in the recognition of amyloid precursor protein. NCT is incorporated into the γ-secretase complex in the ... [more]
J. Biol. Chem. Dec. 28, 2012; 287(53);44203-11 [Pubmed: 23129766]
Throughput
- Low Throughput
Curated By
- BioGRID