BAIT
PIAS3
ZMIZ5
protein inhibitor of activated STAT, 3
GO Process (2)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HIC1
ZBTB29, ZNF901, hic-1
hypermethylated in cancer 1
GO Process (5)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [ISS]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.
Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in lung cancer metastasis. The class III deacetylase sirtuin 1 (SIRT1) possesses both pro- and anticarcinogenic properties. The role of SIRT1 in lung cancer EMT is largely undefined.The effect of SIRT1 on migration of lung cancer cells was evaluated by wound healing assay in vitro and metastasis assay in nude mice in vivo. ... [more]
J. Natl. Cancer Inst. Jun. 19, 2013; 105(12);887-98 [Pubmed: 23704280]
Throughput
- Low Throughput
Curated By
- BioGRID