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BAIT

SRR

Srs, RP23-174M12.5

serine racemase

GO Process (7)

GO Function (12)

GO Component (4)

Gene Ontology Biological Process

D-serine biosynthetic process [IDA, ISO]

D-serine metabolic process [ISO]

L-serine metabolic process [IDA, ISO]

brain development [IBA]

protein homotetramerization [IDA]

pyruvate biosynthetic process [ISO]

serine family amino acid metabolic process [IDA]

Gene Ontology Molecular Function

ATP binding [IDA, ISO]
D-serine ammonia-lyase activity [IBA]
L-serine ammonia-lyase activity [IBA, ISO]
PDZ domain binding [ISO]
calcium ion binding [IDA]
glycine binding [IDA]
magnesium ion binding [ISO]
protein binding [IPI]
protein homodimerization activity [IDA, ISO]
pyridoxal phosphate binding [IMP, ISO]
serine racemase activity [IDA, ISO]
threonine racemase activity [IDA]

Gene Ontology Cellular Component

apical part of cell [ISO]

cytoplasm [IBA, ISO]

neuronal cell body [IBA, ISO]

plasma membrane [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

FBXO22

FBX22, FISTC1

F-box protein 22

GO Process (2)

GO Function (1)

GO Component (0)

Gene Ontology Biological Process

cellular protein modification process [TAS]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

ubiquitin-protein transferase activity [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FBXO22 is Required for Optimal Synthesis of the NMDA Receptor Co-agonist D-Serine.

Dikopoltsev E, Foltyn VN, Zehl M, Jensen ON, Mori H, Radzishevsky I, Wolosker H

D-Serine is a physiological activator of NMDA receptors (NMDARs) in the nervous system that mediates several NMDAR-mediated processes, ranging from normal neurotransmission to neurodegeneration. D-Serine is synthesized from L-serine by serine racemase (SR), a brain-enriched enzyme. Yet, little is known about the regulation of D-serine synthesis. We now demonstrate that the F-box only protein 22 (FBXO22) interacts with SR and ... [more]

J. Biol. Chem. Oct. 21, 2014; 0(0); [Pubmed: 25336657]

Throughput

Low Throughput

Curated By

BioGRID