SRR
Gene Ontology Biological Process
- D-serine biosynthetic process [ISO]
- D-serine metabolic process [IDA, ISO]
- L-serine metabolic process [IDA, ISO]
- aging [IEP]
- brain development [IEP]
- protein homotetramerization [ISO]
- pyruvate biosynthetic process [ISO]
- response to drug [IEP]
- response to lipopolysaccharide [ISO]
- response to morphine [IEP]
- response to organic cyclic compound [IEP]
- serine family amino acid metabolic process [ISO]
Gene Ontology Molecular Function- ATP binding [IDA, ISO]
- L-serine ammonia-lyase activity [ISO]
- PDZ domain binding [ISO]
- calcium ion binding [ISO]
- glycine binding [ISO]
- magnesium ion binding [IDA, ISO]
- protein homodimerization activity [IPI, ISO]
- pyridoxal phosphate binding [IDA, ISO]
- serine racemase activity [IDA, ISO]
- threonine racemase activity [ISO]
- ATP binding [IDA, ISO]
- L-serine ammonia-lyase activity [ISO]
- PDZ domain binding [ISO]
- calcium ion binding [ISO]
- glycine binding [ISO]
- magnesium ion binding [IDA, ISO]
- protein homodimerization activity [IPI, ISO]
- pyridoxal phosphate binding [IDA, ISO]
- serine racemase activity [IDA, ISO]
- threonine racemase activity [ISO]
Gene Ontology Cellular Component
FBXO22
Gene Ontology Biological Process
- cellular response to starvation [ISO]
- nucleocytoplasmic transport [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- protein polyubiquitination [ISO]
- regulation of myotube differentiation [ISO]
- regulation of skeletal muscle fiber development [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
FBXO22 is Required for Optimal Synthesis of the NMDA Receptor Co-agonist D-Serine.
D-Serine is a physiological activator of NMDA receptors (NMDARs) in the nervous system that mediates several NMDAR-mediated processes, ranging from normal neurotransmission to neurodegeneration. D-Serine is synthesized from L-serine by serine racemase (SR), a brain-enriched enzyme. Yet, little is known about the regulation of D-serine synthesis. We now demonstrate that the F-box only protein 22 (FBXO22) interacts with SR and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID