BAIT
ERLIN2
C8orf2, Erlin-2, NET32, SPFH2, SPG18, UNQ2441
ER lipid raft associated 2
GO Process (1)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TIMM50
TIM50, TIM50L, PRO1512
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
GO Process (6)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Membrane-associated Ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway in the yeast Saccharomyces cerevisiae is mediated by two membrane-bound ubiquitin ligases, Doa10 and Hrd1. These enzymes are found in distinct multiprotein complexes that allow them to recognize and target a variety of substrates for proteasomal degradation. Although multiprotein complexes containing mammalian ERAD ubiquitin ligases likely exist, they have yet to be identified ... [more]
Unknown Feb. 22, 2011; 0(0); [Pubmed: 21343306]
Throughput
- High Throughput
Curated By
- BioGRID