BAIT
FBXW11
BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos
F-box and WD repeat domain containing 11
GO Process (12)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- mitotic cell cycle [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of proteolysis [IMP]
- positive regulation of transcription, DNA-templated [ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein dephosphorylation [ISS]
- protein destabilization [IMP]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ELMO2
CED-12, CED12, ELMO-2, RP11-394O2.2
engulfment and cell motility 2
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase.
Defining the full complement of substrates for each ubiquitin ligase remains an important challenge. Improvements in mass spectrometry instrumentation, computation and protein biochemistry methods have resulted in several new methods for ubiquitin ligase substrate identification. Here we used the parallel adapter capture (PAC) proteomics approach to study βTrCP2/FBXW11, a substrate adaptor for the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex. The ... [more]
Mol. Cell. Biol. Oct. 20, 2014; 0(0); [Pubmed: 25332235]
Throughput
- High Throughput
Curated By
- BioGRID