BAIT
ELG1
RTT110, S000007438, YOR144C
Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
GO Process (7)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
PPS1
tyrosine/serine/threonine protein phosphatase PPS1, L000003522, YBR276C
Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IBA]
- inactivation of MAPK activity [IDA, IMP]
- nuclear DNA replication [IMP]
- protein dephosphorylation [IDA]
- regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IBA]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast.
Elg1 and Srs2 are two proteins involved in maintaining genome stability in yeast. After DNA damage, the homotrimeric clamp PCNA, which provides stability and processivity to DNA polymerases and serves as a docking platform for DNA repair enzymes, undergoes modification by the ubiquitin-like molecule SUMO. PCNA SUMOylation helps recruit Srs2 and Elg1 to the replication fork. In the absence of ... [more]
G3 (Bethesda) May. 01, 2013; 3(5);917-26 [Pubmed: 23704284]
Throughput
- Low Throughput
Additional Notes
- high-copy suppressor of elg1 srs2 double mutants (sectoring screen)
Curated By
- BioGRID