BAIT
ALS2
3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563
amyotrophic lateral sclerosis 2 (juvenile)
GO Process (21)
GO Function (11)
GO Component (20)
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- axonogenesis [ISO]
- behavioral fear response [IMP]
- cell death [ISO]
- endosomal transport [IMP]
- endosome organization [ISO]
- locomotory behavior [IMP]
- lysosomal transport [ISO]
- neuromuscular junction development [IMP]
- neuron projection morphogenesis [ISO]
- positive regulation of Rab GTPase activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein homooligomerization [ISO]
- protein localization [IMP]
- receptor recycling [IMP]
- regulation of Rab GTPase activity [IDA]
- response to oxidative stress [IMP]
- synaptic transmission, glutamatergic [IMP]
- vesicle organization [IDA]
Gene Ontology Molecular Function- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic spine [IDA]
- early endosome [ISO]
- growth cone [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- lamellipodium [IDA]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- ruffle [IDA]
- vesicle [ISO]
Mus musculus
PREY
GRIA2
GluA2, GluR-B, Glur-2, Glur2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
GO Process (10)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- establishment of protein localization [ISO]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- positive regulation of synaptic transmission [ISO]
- protein tetramerization [ISO]
- receptor internalization [ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- synaptic transmission [IDA, ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- cell surface [ISO]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [ISO]
- perikaryon [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, IDA]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [ISO]
- terminal bouton [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease is caused by a selective loss of motor neurons. One form of juvenile onset autosomal recessive ALS (ALS2) has been linked to the loss of function of the ALS2 gene. The pathogenic mechanism of ALS2-deficiency, however, remains unclear. To further understand the function of alsin that is encoded by ... [more]
J. Neurosci. Nov. 08, 2006; 26(45);11798-806 [Pubmed: 17093100]
Throughput
- Low Throughput
Curated By
- BioGRID