BAIT
ALS2
3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563
amyotrophic lateral sclerosis 2 (juvenile)
GO Process (21)
GO Function (11)
GO Component (20)
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- axonogenesis [ISO]
- behavioral fear response [IMP]
- cell death [ISO]
- endosomal transport [IMP]
- endosome organization [ISO]
- locomotory behavior [IMP]
- lysosomal transport [ISO]
- neuromuscular junction development [IMP]
- neuron projection morphogenesis [ISO]
- positive regulation of Rab GTPase activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein homooligomerization [ISO]
- protein localization [IMP]
- receptor recycling [IMP]
- regulation of Rab GTPase activity [IDA]
- response to oxidative stress [IMP]
- synaptic transmission, glutamatergic [IMP]
- vesicle organization [IDA]
Gene Ontology Molecular Function- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic spine [IDA]
- early endosome [ISO]
- growth cone [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- lamellipodium [IDA]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- ruffle [IDA]
- vesicle [ISO]
Mus musculus
PREY
DLG4
Dlgh4, PSD-95, PSD95, SAP90, SAP90A, RP23-172M21.9
discs, large homolog 4 (Drosophila)
GO Process (23)
GO Function (18)
GO Component (24)
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IBA, ISO]
- dendritic spine morphogenesis [IDA, ISO]
- establishment of protein localization [ISO]
- locomotory behavior [NAS]
- locomotory exploration behavior [IMP]
- negative regulation of receptor internalization [ISO]
- neuromuscular process controlling balance [IMP]
- nucleotide phosphorylation [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- protein complex assembly [ISO]
- protein localization to synapse [IDA, ISO]
- receptor localization to synapse [IBA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of grooming behavior [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of neuronal synaptic plasticity [NAS]
- response to cocaine [NAS]
- signal transduction [IBA]
- social behavior [IMP]
- synaptic vesicle maturation [IDA, IGI]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
- D1 dopamine receptor binding [ISO]
- P2Y1 nucleotide receptor binding [ISO]
- PDZ domain binding [ISO]
- acetylcholine receptor binding [ISO]
- beta-1 adrenergic receptor binding [ISO]
- glutamate receptor binding [ISO]
- guanylate kinase activity [IBA]
- ionotropic glutamate receptor binding [IPI, ISO]
- kinase binding [ISO]
- neurexin family protein binding [NAS]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [IPI]
- structural molecule activity [NAS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA]
- cell junction [IDA]
- cerebellar mossy fiber [IDA]
- cortical cytoskeleton [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendrite cytoplasm [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- ionotropic glutamate receptor complex [IDA]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [IDA]
- neuron spine [IDA]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [IDA]
- synaptic vesicle [IDA]
- voltage-gated potassium channel complex [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease is caused by a selective loss of motor neurons. One form of juvenile onset autosomal recessive ALS (ALS2) has been linked to the loss of function of the ALS2 gene. The pathogenic mechanism of ALS2-deficiency, however, remains unclear. To further understand the function of alsin that is encoded by ... [more]
J. Neurosci. Nov. 08, 2006; 26(45);11798-806 [Pubmed: 17093100]
Throughput
- Low Throughput
Curated By
- BioGRID