UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPARGC1A
Gene Ontology Biological Process
- RNA splicing [TAS]
- androgen receptor signaling pathway [NAS]
- brown fat cell differentiation [TAS]
- cellular glucose homeostasis [NAS]
- cellular respiration [TAS]
- cellular response to oxidative stress [ISS]
- circadian regulation of gene expression [ISS]
- digestion [TAS]
- fatty acid oxidation [NAS]
- gluconeogenesis [NAS]
- mRNA processing [TAS]
- mitochondrion organization [NAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of neuron death [IGI]
- positive regulation of ATP biosynthetic process [ISS]
- positive regulation of energy homeostasis [ISS]
- positive regulation of fatty acid oxidation [TAS]
- positive regulation of gluconeogenesis [TAS]
- positive regulation of histone acetylation [TAS]
- positive regulation of mitochondrion organization [IBA, ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein complex assembly [TAS]
- protein stabilization [TAS]
- regulation of circadian rhythm [ISS]
- regulation of transcription, DNA-templated [IDA]
- respiratory electron transport chain [ISS]
- response to muscle activity [ISS]
- response to starvation [NAS]
- temperature homeostasis [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
SUMOylation attenuates the function of PGC-1alpha.
Peroxisome proliferator-activated receptor gamma-coactivator-1alpha (PGC-1alpha) is a key coordinator of gene programs in metabolism and energy homeostasis in mammals. It is highly responsive to changes in the cellular environment and physiological status of mammals and regulated by post-translational modifications: acetylation, phosphorylation, and methylation. Here, we show that PGC-1alpha is covalently modified by small ubiquitin-like modifier (SUMO) 1 protein, an important ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 1D
Curated By
- BioGRID