IFITM3
Gene Ontology Biological Process
- defense response to virus [IDA, IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of viral entry into host cell [IDA, ISO]
- negative regulation of viral genome replication [ISO]
- negative regulation of viral transcription [ISO]
- response to interferon-alpha [ISO]
- response to interferon-beta [ISO]
- response to interferon-gamma [ISO]
- response to virus [IDA, ISO]
- type I interferon signaling pathway [IDA]
Gene Ontology Cellular Component
ATP6V0B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function.
The innate response interferon-inducible transmembrane (Ifitm) proteins have been characterized as influencing proliferation, signaling complexes and restricting virus infections. Treatment of cells lacking these proteins (IfitmDel) with IFN-β resulted in the loss of clathrin from membrane compartments and the inhibition of clathrin-mediated phagocytosis, suggesting a molecular interaction between clathrin and Ifitm proteins. The pH of endosomes of IfitmDel cells, with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID