BAIT
AIP
ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2
aryl hydrocarbon receptor interacting protein
GO Process (4)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAQ
CMC1, G-ALPHA-q, GAQ, SWS, RP11-494N1.1
guanine nucleotide binding protein (G protein), q polypeptide
GO Process (11)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- action potential [IBA]
- activation of phospholipase C activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- glutamate receptor signaling pathway [IBA]
- negative regulation of protein kinase activity [IMP]
- phospholipase C-activating dopamine receptor signaling pathway [IBA]
- platelet activation [TAS]
- positive regulation of GTPase activity [IDA]
- protein stabilization [IMP]
- regulation of catenin import into nucleus [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor.
Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Galpha13 signal destabilizes AhR by promoting the ubiquitination of AhR. Galpha13 interacts directly with AhR-interacting protein (AIP) and inhibits the interaction between AhR and AIP, a crucial interacting ... [more]
EMBO Rep. Jun. 01, 2009; 10(6);622-8 [Pubmed: 19390533]
Throughput
- Low Throughput
Curated By
- BioGRID