ACTN2
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell adhesion [TAS]
- focal adhesion assembly [IMP]
- microspike assembly [IDA]
- muscle filament sliding [TAS]
- negative regulation of potassium ion transmembrane transporter activity [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of protein localization to cell surface [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of apoptotic process [NAS]
- regulation of membrane potential [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNAI1
Gene Ontology Biological Process
- Notch signaling involved in heart development [ISS]
- epithelial to mesenchymal transition [IDA, ISS]
- mesoderm formation [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISS]
- negative regulation of vitamin D biosynthetic process [IDA]
- osteoblast differentiation [IEP]
- positive regulation of cell migration [IMP]
- positive regulation of epithelial to mesenchymal transition [IMP, TAS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of tight junction assembly [IMP]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ACTN2 SNAI1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2700407 |
Curated By
- BioGRID