ACTN2
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell adhesion [TAS]
- focal adhesion assembly [IMP]
- microspike assembly [IDA]
- muscle filament sliding [TAS]
- negative regulation of potassium ion transmembrane transporter activity [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of protein localization to cell surface [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of apoptotic process [NAS]
- regulation of membrane potential [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SP100
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- chromatin remodeling [IBA]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [IC, TAS]
- negative regulation of DNA binding [IDA]
- negative regulation of cellular component movement [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of nucleic acid-templated transcription [IDA]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral transcription [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of Fas signaling pathway [IMP]
- regulation of angiogenesis [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- response to cytokine [IDA]
- response to interferon-gamma [IDA, IMP]
- response to retinoic acid [IDA]
- response to type I interferon [IDA, IMP]
- retinoic acid receptor signaling pathway [IC]
- telomere maintenance [IMP]
- type I interferon signaling pathway [IC]
Gene Ontology Molecular Function- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- chromatin binding [IBA]
- chromo shadow domain binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [IPI]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ACTN2 SP100 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID