BAIT
AES
AES-1, AES-2, ESP1, GRG, GRG5, Grg-5, TLE5
amino-terminal enhancer of split
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- multicellular organismal development [TAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of protein binding [IDA]
- negative regulation of response to cytokine stimulus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- organ morphogenesis [TAS]
- positive regulation of anoikis [IMP]
- response to interleukin-1 [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
SRPK2
SFRSK2
SRSF protein kinase 2
GO Process (14)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- RNA splicing [IDA]
- angiogenesis [ISS]
- innate immune response [IC]
- intracellular signal transduction [IDA]
- negative regulation of viral genome replication [IDA]
- nuclear speck organization [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of viral genome replication [IDA]
- protein phosphorylation [IDA]
- regulation of mRNA splicing, via spliceosome [TAS]
- spliceosomal complex assembly [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Cell Nov. 20, 2014; 159(5);1212-26 [Pubmed: 25416956]
Throughput
- High Throughput
Curated By
- BioGRID