BAIT
CAMK2D
CAMKD
calcium/calmodulin-dependent protein kinase II delta
GO Process (32)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- cardiac muscle cell contraction [ISS]
- cellular response to calcium ion [TAS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum calcium ion homeostasis [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of sodium ion transmembrane transport [IDA]
- negative regulation of sodium ion transmembrane transporter activity [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cardiac muscle hypertrophy [IMP]
- protein autophosphorylation [IDA]
- protein oligomerization [IDA]
- protein phosphorylation [IDA]
- regulation of cardiac muscle cell action potential [ISS]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, TAS]
- regulation of cell communication by electrical coupling [ISS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of cell growth [NAS]
- regulation of cellular localization [IMP]
- regulation of generation of L-type calcium current [ISS]
- regulation of heart contraction [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of histone deacetylase activity [TAS]
- regulation of membrane depolarization [IDA]
- regulation of relaxation of cardiac muscle [IDA]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- regulation of the force of heart contraction [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- relaxation of cardiac muscle [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FKBP1B
FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
FK506 binding protein 1B, 12.6 kDa
GO Process (18)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- calcium ion transmembrane transport [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- chaperone-mediated protein folding [IBA]
- cytosolic calcium ion homeostasis [IDA, IGI]
- negative regulation of heart rate [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of sequestering of calcium ion [IDA]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IBA, ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, IMP]
- response to redox state [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Cell Nov. 20, 2014; 159(5);1212-26 [Pubmed: 25416956]
Throughput
- High Throughput
Curated By
- BioGRID