BAIT
NEFL
CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110
neurofilament, light polypeptide
GO Process (6)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPP1R16B
ANKRD4, TIMAP, RP5-1076E17.1
protein phosphatase 1, regulatory subunit 16B
GO Process (9)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- establishment of endothelial barrier [IMP]
- negative regulation of peptidyl-serine dephosphorylation [IMP]
- negative regulation of protein dephosphorylation [IDA]
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of protein dephosphorylation [IDA]
- regulation of filopodium assembly [ISS]
- regulation of phosphatidylinositol 3-kinase signaling [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Cell Nov. 20, 2014; 159(5);1212-26 [Pubmed: 25416956]
Throughput
- High Throughput
Curated By
- BioGRID