BAIT
PSMA1
HC2, HEL-S-275, NU, PROS30
proteasome (prosome, macropain) subunit, alpha type, 1
GO Process (21)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TCF4
E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19
transcription factor 4
GO Process (6)
GO Function (11)
GO Component (2)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [ISS]
- positive regulation of neuron differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- protein-DNA complex assembly [ISS]
- transcription initiation from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- TFIIB-class binding transcription factor activity [ISS]
- TFIIB-class transcription factor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS, NAS]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Cell Nov. 20, 2014; 159(5);1212-26 [Pubmed: 25416956]
Throughput
- High Throughput
Curated By
- BioGRID