BAIT
UBQLN1
DA41, DSK2, PLIC-1, UBQN, XDRP1
ubiquilin 1
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GHRL
MTLRP, UNQ524/PRO1066
ghrelin/obestatin prepropeptide
GO Process (36)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS, TAS]
- actin polymerization or depolymerization [IDA]
- activation of MAPK activity [IMP]
- adult feeding behavior [ISS]
- cartilage development [NAS]
- cellular protein metabolic process [TAS]
- cortisol secretion [NAS]
- decidualization [IDA]
- dendrite development [IDA]
- gastric acid secretion [IBA]
- glucose metabolic process [NAS]
- growth hormone secretion [TAS]
- hormone-mediated signaling pathway [TAS]
- negative regulation of angiogenesis [NAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of circadian sleep/wake cycle, REM sleep [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of interleukin-6 biosynthetic process [IDA]
- negative regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of appetite [ISS]
- positive regulation of circadian sleep/wake cycle, non-REM sleep [IDA]
- positive regulation of corticotropin secretion [IDA]
- positive regulation of cortisol secretion [IDA]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of growth hormone receptor signaling pathway [IC]
- positive regulation of growth hormone secretion [IDA]
- positive regulation of insulin secretion [ISS]
- positive regulation of multicellular organism growth [IC]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of synapse assembly [IDA]
- regulation of cell proliferation [IDA]
- regulation of response to food [IBA]
- response to estrogen [IDA]
- response to hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A proteome-scale map of the human interactome network.
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand genotype-phenotype relationships. Here, we describe a systematic map of ?14,000 high-quality human binary protein-protein interactions. At equal quality, this map is ?30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently ... [more]
Cell Nov. 20, 2014; 159(5);1212-26 [Pubmed: 25416956]
Throughput
- High Throughput
Curated By
- BioGRID