BAIT
GRIN2A
GluN2A, NMDAR2A, NR2A
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
GO Process (44)
GO Function (19)
GO Component (13)
Gene Ontology Biological Process
- action potential [ISO]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IGI, IMP]
- cation transmembrane transport [ISO]
- cation transport [ISO]
- cellular response to amino acid stimulus [ISO]
- cellular response to zinc ion [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- directional locomotion [IGI]
- dopamine metabolic process [IMP]
- ion transmembrane transport [IGI, ISO]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- learning [IMP]
- learning or memory [IMP]
- locomotion [IMP]
- locomotory behavior [TAS]
- memory [IMP, ISO]
- negative regulation of protein catabolic process [IGI]
- neurogenesis [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell death [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- protein localization [IGI, IMP]
- protein tetramerization [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [IMP]
- regulation of postsynaptic membrane potential [IMP]
- regulation of sensory perception of pain [IMP]
- regulation of synaptic plasticity [IMP]
- regulation of synaptic transmission [IMP]
- response to amphetamine [IMP]
- response to drug [IMP]
- response to ethanol [IMP, ISO]
- response to wounding [IGI, IMP]
- rhythmic process [ISO]
- sensory perception of pain [IMP]
- serotonin metabolic process [IMP]
- sleep [IMP]
- startle response [IGI, IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- calcium channel activity [IGI, IMP]
- cation channel activity [IMP, ISO]
- cell adhesion molecule binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- voltage-gated cation channel activity [ISO]
- zinc ion binding [ISO]
- ATPase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- calcium channel activity [IGI, IMP]
- cation channel activity [IMP, ISO]
- cell adhesion molecule binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- voltage-gated cation channel activity [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- cell surface [IDA]
- dendritic spine [ISA]
- endoplasmic reticulum [IDA]
- membrane [IDA]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA, ISO]
- synapse [IDA]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
Mus musculus
PREY
LRP1
A2mr, AI316852, CD91, Lrp, b2b1554Clo
low density lipoprotein receptor-related protein 1
GO Process (17)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- aorta morphogenesis [IMP]
- apoptotic cell clearance [IMP]
- beta-amyloid clearance [IMP]
- cell proliferation [ISO]
- cholesterol metabolic process [IMP]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of smooth muscle cell migration [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of lipid transport [IMP]
- positive regulation of protein transport [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cholesterol transport [IMP]
- regulation of phospholipase A2 activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
LDL receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.
The lipoprotein receptor LRP1 is essential in neurons of the central nervous system as was revealed by the analysis of conditional Lrp1-deficient mouse models. The molecular basis of its neuronal functions, however, is still incompletely understood. Here we show by immunocytochemistry, electron microscopy, and postsynaptic density (PSD) preparation that LRP1 is located postsynaptically. Basal and NMDA-induced phosphorylation of the transcription ... [more]
J. Biol. Chem. Jun. 11, 2013; 0(0); [Pubmed: 23760271]
Throughput
- Low Throughput
Curated By
- BioGRID