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BAIT

CFTR

ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

GO Process (9)

GO Function (9)

GO Component (10)

Gene Ontology Biological Process

cellular response to cAMP [ISS]

chloride transmembrane transport [IDA, ISS, NAS, TAS]

intracellular pH elevation [ISS]

membrane hyperpolarization [ISS]

positive regulation of voltage-gated chloride channel activity [IDA]

respiratory gaseous exchange [TAS]

sperm capacitation [ISS]

transmembrane transport [TAS]

transport [TAS]

Gene Ontology Molecular Function

ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
PDZ domain binding [IDA]
bicarbonate transmembrane transporter activity [ISS]
channel-conductance-controlling ATPase activity [NAS]
chloride channel activity [IDA]
chloride channel inhibitor activity [IDA]
chloride transmembrane transporter activity [ISS]
enzyme binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

apical plasma membrane [IDA]

basolateral plasma membrane [NAS]

cell surface [IDA]

cytoplasm [IDA]

early endosome [IDA]

endoplasmic reticulum Sec complex [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA, TAS]

protein complex [IDA]

recycling endosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EEA1

MST105, MSTP105, ZFYVE2

early endosome antigen 1

GO Process (4)

GO Function (6)

GO Component (6)

Gene Ontology Biological Process

early endosome to late endosome transport [NAS]

endocytosis [IMP]

synaptic vesicle to endosome fusion [TAS]

vesicle fusion [IMP]

Gene Ontology Molecular Function

1-phosphatidylinositol binding [IDA]
GTP-dependent protein binding [IDA]
calmodulin binding [NAS]
protein binding [IPI]
protein homodimerization activity [IDA]
zinc ion binding [TAS]

Gene Ontology Cellular Component

cytoplasm [TAS]

early endosome [IDA]

extracellular vesicular exosome [IDA]

extrinsic component of plasma membrane [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.

Villella VR, Esposito S, Bruscia EM, Vicinanza M, Cenci S, Guido S, Pettoello-Mantovani M, Carnuccio R, De Matteis MA, Luini A, Maiuri MC, Raia V, Kroemer G, Maiuri L

Mismanaged protein trafficking by the proteostasis network contributes to several conformational diseases, including cystic fibrosis, the most frequent lethal inherited disease in Caucasians. Proteostasis regulators, as cystamine, enable the beneficial action of cystic fibrosis transmembrane conductance regulator (CFTR) potentiators in Î”F508-CFTR airways beyond drug washout. Here we tested the hypothesis that functional CFTR protein can sustain its own plasma membrane ... [more]

Cell Death Differ. May. 17, 2013; 0(0); [Pubmed: 23686137]

Throughput

Low Throughput

Curated By

BioGRID