BAIT
ZFP36
G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
ZFP36 ring finger protein
GO Process (12)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- RNA metabolic process [TAS]
- gene expression [TAS]
- mRNA catabolic process [IDA]
- mRNA metabolic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of translation involved in gene silencing by miRNA [ISS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IDA]
- regulation of tumor necrosis factor production [IDA]
- response to starvation [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
CCL3
G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3
chemokine (C-C motif) ligand 3
GO Process (52)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [IEP, IMP]
- T cell chemotaxis [IDA]
- astrocyte cell migration [ISS]
- behavior [IDA]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell activation [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemotaxis [IDA]
- cytoskeleton organization [IDA]
- eosinophil chemotaxis [IDA]
- eosinophil degranulation [IDA]
- exocytosis [IDA]
- granulocyte chemotaxis [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymphocyte chemotaxis [IDA]
- macrophage chemotaxis [ISS]
- monocyte chemotaxis [IC, IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of bone mineralization [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of osteoclast differentiation [IDA]
- neutrophil chemotaxis [IDA]
- osteoblast differentiation [IEP]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of calcium ion import [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of inflammatory response [ISS]
- positive regulation of interleukin-1 beta secretion [ISS]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein kinase B signaling [IEP]
- positive regulation of tumor necrosis factor production [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of sensory perception of pain [IDA]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IDA]
- response to toxic substance [IDA]
- signaling [IEP]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.
Zinc finger protein tristetraprolin (TTP) modulates macrophage inflammatory activity by destabilizing cytokine mRNAs. In this study, through a screen of TTP-bound mRNAs in activated human macrophages, we have identified CCL3 mRNA as the most abundantly bound TTP target mRNA and have characterized this interaction via conserved AU-rich elements. Compared to the wild-type cells, TTP(-/-) macrophages produced higher levels of LPS-induced ... [more]
J. Immunol. Sep. 01, 2011; 187(5);2696-701 [Pubmed: 21784977]
Throughput
- Low Throughput
Curated By
- BioGRID