BAIT

MAPRE1

EB1
microtubule-associated protein, RP/EB family, member 1
Homo sapiens
PREY

ABCB1

ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Glioblastoma Project
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

CYLD coordinates with EB1 to regulate microtubule dynamics and cell migration.

Li D, Gao J, Yang Y, Sun L, Suo S, Luo Y, Shui W, Zhou J, Liu M

Cylindromatosis (CYLD), a deubiquitinase involved in inflammation and tumorigenesis via the modulation of cell signaling, has recently been identified as a critical regulator of microtubule dynamics. CYLD has also been shown to stimulate cell migration and thereby contribute to normal physiological processes. However, it remains elusive how the regulation of microtubule dynamic properties by CYLD is connected to its role ... [more]

Cell Cycle Mar. 15, 2014; 13(6);974-83 [Pubmed: 24552808]

Throughput

  • High Throughput|Low Throughput

Additional Notes

  • source of CYLD not clear

Curated By

  • BioGRID