BAIT
MAPRE1
EB1
microtubule-associated protein, RP/EB family, member 1
GO Process (5)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BCL3
BCL4, D19S37
B-cell CLL/lymphoma 3
GO Process (17)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IMP]
- I-kappaB kinase/NF-kappaB signaling [IDA]
- cellular response to DNA damage stimulus [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- maintenance of protein location in nucleus [NAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of interleukin-8 biosynthetic process [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of translation [IMP]
- protein import into nucleus, translocation [IMP]
- regulation of DNA binding [IEP]
- regulation of NF-kappaB import into nucleus [IEP]
- regulation of apoptotic process [IDA]
- response to UV-C [IDA]
- response to virus [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
CYLD coordinates with EB1 to regulate microtubule dynamics and cell migration.
Cylindromatosis (CYLD), a deubiquitinase involved in inflammation and tumorigenesis via the modulation of cell signaling, has recently been identified as a critical regulator of microtubule dynamics. CYLD has also been shown to stimulate cell migration and thereby contribute to normal physiological processes. However, it remains elusive how the regulation of microtubule dynamic properties by CYLD is connected to its role ... [more]
Cell Cycle Mar. 15, 2014; 13(6);974-83 [Pubmed: 24552808]
Throughput
- High Throughput|Low Throughput
Additional Notes
- source of CYLD not clear
Curated By
- BioGRID