NSD1
Gene Ontology Biological Process
Gene Ontology Molecular Function- androgen receptor binding [IDA]
- chromatin binding [ISS]
- estrogen receptor binding [ISS]
- histone methyltransferase activity (H3-K36 specific) [IDA, ISS]
- histone methyltransferase activity (H4-K20 specific) [ISS]
- retinoic acid receptor binding [ISS]
- retinoid X receptor binding [ISS]
- thyroid hormone receptor binding [ISS]
- transcription cofactor activity [IDA]
- transcription corepressor activity [ISS]
- zinc ion binding [IDA]
- androgen receptor binding [IDA]
- chromatin binding [ISS]
- estrogen receptor binding [ISS]
- histone methyltransferase activity (H3-K36 specific) [IDA, ISS]
- histone methyltransferase activity (H4-K20 specific) [ISS]
- retinoic acid receptor binding [ISS]
- retinoid X receptor binding [ISS]
- thyroid hormone receptor binding [ISS]
- transcription cofactor activity [IDA]
- transcription corepressor activity [ISS]
- zinc ion binding [IDA]
ATRX
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA damage response, signal transduction by p53 class mediator [ISS]
- DNA duplex unwinding [TAS]
- DNA methylation [TAS]
- DNA recombination [TAS]
- DNA replication-independent nucleosome assembly [IMP]
- cellular response to hydroxyurea [ISS]
- chromatin remodeling [IDA]
- negative regulation of telomeric RNA transcription from RNA pol II promoter [ISS]
- nucleosome assembly [IDA]
- positive regulation of nuclear cell cycle DNA replication [ISS]
- positive regulation of telomere maintenance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [TAS]
- replication fork processing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Methylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1.
The nuclear receptor binding SET [su(var) 3-9, enhancer of zeste, trithorax] domain-containing protein 1 (NSD1) protein lysine methyltransferase (PKMT) was known to methylate histone H3 lysine 36 (H3K36). We show here that NSD1 prefers aromatic, hydrophobic, and basic residues at the -2, -1 and +2, and +1 sites of its substrate peptide, respectively. We show methylation of 25 nonhistone peptide ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID