AP1G1
Gene Ontology Biological Process
- Golgi to lysosome transport [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- endosome to melanosome transport [IMP]
- melanosome organization [IC]
- membrane organization [TAS]
- positive regulation of natural killer cell degranulation [IMP]
- positive regulation of natural killer cell mediated cytotoxicity [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of defense response to virus by virus [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-type membrane coat adaptor complex [TAS]
- Golgi apparatus [IDA]
- Golgi membrane [TAS]
- clathrin-coated vesicle [IDA]
- clathrin-coated vesicle membrane [ISS]
- cytoplasm [IDA]
- cytoplasmic vesicle membrane [TAS]
- cytosol [TAS]
- intracellular membrane-bounded organelle [IDA]
- lysosomal membrane [TAS]
- membrane [IDA]
- recycling endosome [IDA]
- trans-Golgi network membrane [TAS]
CORO7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi.
Crn7 is a novel cytosolic mammalian WD-repeat protein of unknown function that associates with Golgi membranes. Here, we demonstrate that Crn7 knockdown by small interfering RNA results in dramatic changes in the Golgi morphology and function. First, the Golgi ribbon is disorganized in Crn7 KD cells. Second, the Golgi export of several marker proteins including VSV envelope G glycoprotein is ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CORO7 AP1G1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID