ALK
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [TAS]
- activation of MAPK activity [TAS]
- cell proliferation [TAS]
- neuron development [TAS]
- peptidyl-tyrosine phosphorylation [IDA, TAS]
- phosphorylation [IDA, TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein autophosphorylation [IDA, TAS]
- regulation of apoptotic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BICD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.
Translocations of the anaplastic lymphoma kinase (ALK) gene have been described in anaplastic large-cell lymphomas (ALCLs) and in stromal tumors. The most frequent translocation, t(2;5), generates the fusion protein nucleophosmin (NPM)-ALK with intrinsic tyrosine kinase activity. Along with transformation, NPM-ALK induces morphologic changes in fibroblasts and lymphoid cells, suggesting a direct role of ALK in cell shaping. In this study, ... [more]
Throughput
- High Throughput
Additional Notes
- pulled down by an NPM-ALK fusion protein
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ALK BICD2 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3769929 |
Curated By
- BioGRID