BAIT
MMS19
MET18, MMS19L, hMMS19, RP11-452K12.5
MMS19 nucleotide excision repair homolog (S. cerevisiae)
GO Process (11)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA metabolic process [IMP]
- DNA repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome segregation [IMP]
- iron-sulfur cluster assembly [IMP]
- nucleotide-excision repair [NAS, TAS]
- phosphorelay signal transduction system [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- response to hormone [NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NDUFS2
CI-49
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
GO Process (5)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
The function of many DNA metabolism proteins depends on their ability to coordinate an iron-sulfur (Fe-S) cluster. Biogenesis of Fe-S proteins is a multistep process that takes place in mitochondria and the cytoplasm, but how it is linked to nuclear Fe-S proteins is not known. Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins ... [more]
Science Jul. 13, 2012; 337(6091);243-5 [Pubmed: 22678361]
Throughput
- Low Throughput
Curated By
- BioGRID