CDK6
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- astrocyte development [ISS]
- cell cycle arrest [TAS]
- cell dedifferentiation [IMP]
- dentate gyrus development [ISS]
- generation of neurons [ISS]
- gliogenesis [IMP]
- lateral ventricle development [ISS]
- mitotic cell cycle [TAS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell differentiation [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of cellular senescence [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of osteoblast differentiation [IDA]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of fibroblast proliferation [IMP]
- protein phosphorylation [IDA]
- regulation of cell motility [ISS]
- regulation of erythrocyte differentiation [IMP]
- regulation of gene expression [IDA, IMP]
- response to virus [IEP]
- type B pancreatic cell development [IDA]
Gene Ontology Molecular Function
HIST1H1A
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
p300 is required for orderly G1/S transition in human cancer cells.
The role of the transcriptional coactivator p300 in cell cycle control has not been analysed in detail due to the lack of appropriate experimental systems. We have now examined cell cycle progression of p300-deficient cancer cell lines, where p300 was disrupted either by gene targeting (p300(-) cells) or knocked down using RNAi. Despite significant proliferation defects under normal growth conditions, ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDK6 HIST1H1A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 796762 |
Curated By
- BioGRID