PELI2
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of protein phosphorylation [IDA]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
TRAF6
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IMP, TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of NF-kappaB-inducing kinase activity [IMP]
- activation of protein kinase activity [IDA]
- apoptotic signaling pathway [TAS]
- cellular response to lipopolysaccharide [IDA]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, TAS]
- positive regulation of JUN kinase activity [IDA, NAS]
- positive regulation of NF-kappaB transcription factor activity [IDA, IMP, TAS]
- positive regulation of T cell activation [IC]
- positive regulation of T cell cytokine production [IMP]
- positive regulation of apoptotic process [TAS]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, NAS]
- positive regulation of transcription regulatory region DNA binding [IDA]
- protein K63-linked ubiquitination [IDA, IGI]
- protein autoubiquitination [IDA, TAS]
- protein polyubiquitination [IDA]
- response to interleukin-1 [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- histone deacetylase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- tumor necrosis factor receptor binding [IPI]
- ubiquitin conjugating enzyme binding [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [EXP, IDA, TAS]
- histone deacetylase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- tumor necrosis factor receptor binding [IPI]
- ubiquitin conjugating enzyme binding [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [EXP, IDA, TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.
The four mammalian Pellinos (Pellinos 1, 2, 3a, and 3b) are E3 ubiquitin ligases that are emerging as critical mediators for a variety of immune signaling pathways, including those activated by Toll-like receptors, the T-cell receptor, and NOD2. It is becoming increasingly clear that each Pellino has a distinct role in facilitating immune receptor signaling. However, the underlying mechanisms by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PELI2 TRAF6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PELI2 TRAF6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID