BAIT
CREB1
Creb
cAMP responsive element binding protein 1
GO Process (33)
GO Function (15)
GO Component (7)
Gene Ontology Biological Process
- Type I pneumocyte differentiation [ISO]
- axonogenesis [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to zinc ion [ISO]
- circadian rhythm [IEP, ISO]
- lactation [ISO]
- lung epithelium development [ISO]
- lung saccule development [ISO]
- mammary gland development [ISO]
- memory [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- pituitary gland development [ISO]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- positive regulation of fat cell differentiation [ISO, ISS]
- positive regulation of hormone secretion [ISO]
- positive regulation of lipid biosynthetic process [ISO, ISS]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation of transforming growth factor beta3 production [IMP]
- protein phosphorylation [ISO]
- protein stabilization [ISO, ISS]
- regulation of apoptotic process [IDA]
- regulation of cell size [ISO]
- regulation of circadian rhythm [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to drug [ISO]
- response to glucagon [ISO, ISS]
- response to organic substance [ISO]
- secretory granule organization [ISO]
- transcription from RNA polymerase II promoter [IMP, ISO]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- cAMP response element binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- histone acetyltransferase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [ISO]
- cAMP response element binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- histone acetyltransferase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
HSPA1A
HSP72, Hsp70-1, Hspa1, Hspa1b
heat shock 70kD protein 1A
GO Process (24)
GO Function (15)
GO Component (22)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA repair [ISO]
- binding of sperm to zona pellucida [ISO]
- cellular heat acclimation [ISO]
- cellular response to heat [ISO]
- defense response [IDA]
- mRNA catabolic process [ISO, ISS]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of inclusion body assembly [ISO]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of erythrocyte differentiation [ISO]
- protein refolding [ISO]
- regulation of cell death [ISO]
- response to heat [ISO]
- response to unfolded protein [IMP, ISO, ISS]
- telomere maintenance [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [ISO]
- G-protein coupled receptor binding [ISO]
- NF-kappaB binding [IPI]
- double-stranded RNA binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [ISO]
- G-protein coupled receptor binding [ISO]
- NF-kappaB binding [IPI]
- double-stranded RNA binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [IPI]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- aggresome [ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- blood microparticle [ISO]
- cell body [ISO]
- centriole [ISO]
- cytoplasm [ISO, ISS]
- cytosol [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- inclusion body [ISO]
- intracellular [ISO]
- mitochondrion [ISO]
- nuclear speck [ISO, ISS]
- nucleus [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO, ISS]
- protein complex [IDA]
- ribonucleoprotein complex [ISO]
- ubiquitin ligase complex [ISO]
- vesicle [ISO]
- zona pellucida receptor complex [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.
Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established. Here we report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements (CREs) found within the mitochondrial genome. Disruption of CREB activity in the mitochondria decreases the expression ... [more]
J. Biol. Chem. Dec. 09, 2005; 280(49);40398-401 [Pubmed: 16207717]
Throughput
- Low Throughput
Additional Notes
- Figure S2
Curated By
- BioGRID