BAIT

NUPR1

COM1, P8
nuclear protein, transcriptional regulator, 1
GO Process (1)
GO Function (0)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

MAPRE1

EB1
microtubule-associated protein, RP/EB family, member 1
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.

Gironella M, Malicet C, Cano C, Sandi MJ, Hamidi T, Tauil RM, Baston M, Valaco P, Moreno S, Lopez F, Neira JL, Dagorn JC, Iovanna JL

The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In this work we describe another example of such mechanism, by which p8 binds and negatively regulates MSL1, a histone acetyl transferase (HAT)-associated protein, ... [more]

J. Cell. Physiol. Dec. 01, 2009; 221(3);594-602 [Pubmed: 19650074]

Throughput

  • Low Throughput

Curated By

  • BioGRID