EP300
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- apoptotic process [ISO]
- cellular response to antibiotic [IEP]
- cellular response to cAMP [IEP]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to drug [IEP]
- cellular response to glucose stimulus [IEP]
- cellular response to hydrogen peroxide [IEP]
- cellular response to mineralocorticoid stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to retinoic acid [IEP]
- cellular response to trichostatin A [IEP]
- circadian rhythm [ISO]
- digestive tract development [IEP]
- heart development [ISO]
- histone H2B acetylation [ISO]
- histone H3 acetylation [IMP]
- histone H4 acetylation [ISO]
- histone acetylation [IMP]
- internal peptidyl-lysine acetylation [IMP, ISO]
- internal protein amino acid acetylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- liver development [IEP]
- lung development [ISO]
- memory [IEP]
- negative regulation of cell death [IMP]
- negative regulation of cellular metabolic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of miRNA metabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- organ morphogenesis [ISO]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA binding [IMP]
- positive regulation of axon extension [IMP]
- positive regulation of cell death [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of cell size [IMP]
- positive regulation of cellular metabolic process [IMP]
- positive regulation of collagen biosynthetic process [IMP]
- positive regulation of gene expression [IDA, IMP]
- positive regulation of glycoprotein biosynthetic process [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of muscle atrophy [IMP]
- positive regulation of protein acetylation [IMP]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein secretion [IMP]
- positive regulation of proteolysis [IMP]
- positive regulation of sarcomere organization [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of translation [IMP]
- protein kinase B signaling [IDA]
- protein-DNA complex assembly [IDA]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of angiotensin metabolic process [IDA]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of transcription, DNA-templated [ISO]
- regulation of tubulin deacetylation [ISO]
- response to calcium ion [IMP]
- response to cobalt ion [IEP]
- response to dexamethasone [IMP]
- response to drug [IMP]
- response to estrogen [IEP, ISO]
- response to ethanol [IEP]
- response to fatty acid [IEP]
- response to glucose [IMP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP, ISO]
- response to organic cyclic compound [IEP]
- response to retinoic acid [IEP]
- response to tumor necrosis factor [IEP]
- skeletal muscle tissue development [ISO]
- somitogenesis [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- NF-kappaB binding [IPI]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI]
- acetyltransferase activity [ISO]
- activating transcription factor binding [IPI, ISO]
- androgen receptor binding [ISO]
- antigen binding [IDA]
- bHLH transcription factor binding [IPI]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA, ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- core promoter proximal region DNA binding [IDA]
- glucocorticoid receptor binding [IDA]
- histone acetyltransferase activity [IDA, ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IMP, ISO]
- mitogen-activated protein kinase binding [IPI]
- nuclear hormone receptor binding [ISO]
- p53 binding [IPI, ISO]
- peroxisome proliferator activated receptor binding [IDA]
- pre-mRNA intronic binding [ISO]
- protein antigen binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription coactivator activity [ISO]
- transcription factor binding [IDA, IPI, ISO]
- transferase activity, transferring acyl groups [ISO]
- DNA binding [ISO]
- NF-kappaB binding [IPI]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI]
- acetyltransferase activity [ISO]
- activating transcription factor binding [IPI, ISO]
- androgen receptor binding [ISO]
- antigen binding [IDA]
- bHLH transcription factor binding [IPI]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA, ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- core promoter proximal region DNA binding [IDA]
- glucocorticoid receptor binding [IDA]
- histone acetyltransferase activity [IDA, ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IMP, ISO]
- mitogen-activated protein kinase binding [IPI]
- nuclear hormone receptor binding [ISO]
- p53 binding [IPI, ISO]
- peroxisome proliferator activated receptor binding [IDA]
- pre-mRNA intronic binding [ISO]
- protein antigen binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription coactivator activity [ISO]
- transcription factor binding [IDA, IPI, ISO]
- transferase activity, transferring acyl groups [ISO]
Gene Ontology Cellular Component
ATF5
Gene Ontology Biological Process
- multicellular organism growth [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of neurogenesis [IDA]
- olfactory bulb interneuron development [ISO]
- olfactory bulb interneuron differentiation [ISO]
- olfactory lobe development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- post-embryonic development [ISO]
- regulation of cell cycle [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival.
ATF5 has been shown to be a critical regulator of cell proliferation and survival; however, the underlying mechanism remains largely unknown. We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding of the ATF5/p300 complex to the ATF5 response element (ARE) ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATF5 EP300 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1055201 |
Curated By
- BioGRID