BAIT
PHF6
BFLS, BORJ, CENP-31, AC004383.6
PHD finger protein 6
GO Process (0)
GO Function (9)
GO Component (3)
Gene Ontology Molecular Function
Homo sapiens
PREY
PCBP2
HNRNPE2, HNRPE2, hnRNP-E2
poly(rC) binding protein 2
GO Process (8)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- RNA splicing [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- mRNA metabolic process [NAS]
- mRNA splicing, via spliceosome [TAS]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex.
Mutations in PHF6 are the cause of Boerjeson-Forssman-Lehman syndrome (BFLS), an X-linked intellectual disability (XLID) disorder, and both T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). The PHF6 gene encodes a protein with two plant homeodomain (PHD)-like zinc finger domains. As many PHD-like domains function to target chromatin remodelers to post-translationally modified histones, this suggests a role for ... [more]
J. Proteome Res. Aug. 03, 2012; 11(8);4326-37 [Pubmed: 22720776]
Throughput
- Low Throughput
Curated By
- BioGRID