BAIT
PTF1A
PACA, PAGEN2, PTF1-p48, bHLHa29
pancreas specific transcription factor, 1a
GO Process (9)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- amacrine cell differentiation [ISS]
- cerebellum development [IMP]
- endocrine pancreas development [TAS]
- exocrine pancreas development [ISS]
- pancreas development [IMP]
- regulation of neural retina development [ISS]
- regulation of transcription, DNA-templated [ISS]
- retina layer formation [ISS]
- tissue development [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
AAMP
angio-associated, migratory cell protein
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The E3 ubiquitin ligase Thyroid hormone Receptor-Interacting Protein 12 targets Pancreas Transcription Factor 1a for Proteasomal Degradation.
Pancreas transcription factor 1a (PTF1a) plays a crucial role in the early development of the pancreas and in the maintenance of the acinar cell phenotype. Several transcriptional mechanisms regulating expression of PTF1a have been identified. However, regulation of PTF1a protein stability and degradation is still unexplored. Here, we report that inhibition of proteasome leads to elevated levels of PTF1a and ... [more]
J. Biol. Chem. Oct. 29, 2014; 0(0); [Pubmed: 25355311]
Throughput
- Low Throughput
Curated By
- BioGRID