MBD4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UHRF1
Gene Ontology Biological Process
- cell proliferation [IEP]
- histone monoubiquitination [ISS]
- histone ubiquitination [IDA]
- maintenance of DNA methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [IC]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IC]
- protein autoubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function- core promoter proximal region sequence-specific DNA binding [IDA]
- hemi-methylated DNA-binding [IDA]
- histone binding [IDA]
- identical protein binding [ISS]
- methyl-CpG binding [IDA]
- methylated histone binding [IDA]
- nucleosomal histone binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- ubiquitin-protein transferase activity [IDA, ISS]
- zinc ion binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- hemi-methylated DNA-binding [IDA]
- histone binding [IDA]
- identical protein binding [ISS]
- methyl-CpG binding [IDA]
- methylated histone binding [IDA]
- nucleosomal histone binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- ubiquitin-protein transferase activity [IDA, ISS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MBD4 Interacts with and Recruits USP7 to heterochromatic foci.
MBD4 is the only methyl-CpG binding protein that possesses a C-terminal glycosylase domain. It has been associated with a number of nuclear pathways including DNA repair, DNA damage response, the initiation of apoptosis, transcriptional repression, and DNA demethylation. However, the precise contribution of MBD4 to these processes in development and relevant diseases remains elusive. We identified UHRF1 and USP7 as ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID