RET
Gene Ontology Biological Process
- MAPK cascade [ISO]
- Peyer's patch morphogenesis [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cellular response to retinoic acid [ISO]
- embryonic epithelial tube formation [ISO]
- enteric nervous system development [ISO]
- innervation [IMP]
- membrane protein proteolysis [ISO]
- nervous system development [ISO]
- neural crest cell migration [ISO]
- neuron cell-cell adhesion [ISO]
- neuron differentiation [ISO]
- neuron maturation [ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell size [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of metanephric glomerulus development [ISO]
- positive regulation of neuron maturation [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of axonogenesis [ISO]
- regulation of cell adhesion [ISO]
- response to drug [IEP]
- response to pain [ISO]
- retina development in camera-type eye [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- ureter maturation [ISO]
- ureteric bud development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AIP
Gene Ontology Biological Process
- negative regulation of cyclic-nucleotide phosphodiesterase activity [IDA]
- protein maturation by protein folding [ISO, ISS]
- protein targeting to mitochondrion [ISO, ISS]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of protein kinase A signaling [IDA]
- xenobiotic metabolic process [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.
CONTEXT: RET is a tyrosine kinase transmembrane receptor expressed in two main alternative isoforms: RET9 and RET51. RET transduces a positive signal leading to survival, differentiation, or migration in the presence of its ligand glial cell line-derived neurotrophic factor, whereas in its absence a proapoptotic fragment that initiates a negative signaling for apoptosis is generated. The signal transduction mechanisms leading ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 3
Curated By
- BioGRID