BIRC5
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- cell division [IMP]
- cytokinesis [IMP]
- establishment of chromosome localization [IMP]
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell proliferation [TAS]
- positive regulation of exit from mitosis [IMP]
- positive regulation of mitotic cell cycle [IMP]
- protein complex localization [IMP]
- protein phosphorylation [IDA]
- protein ubiquitination [IBA]
- regulation of signal transduction [IBA]
- spindle assembly involved in mitosis [IBA]
- spindle checkpoint [IMP]
Gene Ontology Molecular Function- Ran GTPase binding [IPI]
- chaperone binding [IPI]
- cobalt ion binding [NAS]
- cofactor binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- identical protein binding [IPI]
- microtubule binding [IDA, TAS]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, IPI]
- tubulin binding [IDA]
- ubiquitin-protein transferase activity [IBA]
- zinc ion binding [IDA, NAS]
- Ran GTPase binding [IPI]
- chaperone binding [IPI]
- cobalt ion binding [NAS]
- cofactor binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- enzyme binding [IPI]
- identical protein binding [IPI]
- microtubule binding [IDA, TAS]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, IPI]
- tubulin binding [IDA]
- ubiquitin-protein transferase activity [IBA]
- zinc ion binding [IDA, NAS]
Gene Ontology Cellular Component
- centriole [IDA]
- chromosome passenger complex [IPI]
- chromosome, centromeric region [IDA]
- condensed chromosome kinetochore [IDA]
- cytoplasm [IDA]
- cytoplasmic microtubule [IDA]
- cytosol [IDA, TAS]
- interphase microtubule organizing center [IDA]
- midbody [IDA]
- nuclear chromosome [IDA]
- nucleus [IDA]
- spindle microtubule [IDA]
AIP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.
CONTEXT: RET is a tyrosine kinase transmembrane receptor expressed in two main alternative isoforms: RET9 and RET51. RET transduces a positive signal leading to survival, differentiation, or migration in the presence of its ligand glial cell line-derived neurotrophic factor, whereas in its absence a proapoptotic fragment that initiates a negative signaling for apoptosis is generated. The signal transduction mechanisms leading ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID