BAIT
ZDHHC17
HIP14, HIP3, HYPH, HSPC294
zinc finger, DHHC-type containing 17
GO Process (5)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADD1
ADDA, RP11-520M5.1
adducin 1 (alpha)
GO Process (9)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton organization [IC]
- actin filament bundle assembly [IDA]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- apoptotic process [TAS]
- barbed-end actin filament capping [IDA]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- positive regulation of protein binding [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT). HIP14 is dysfunctional in the presence of mutant HTT (mHTT), the causative gene for Huntington disease (HD), and we hypothesize that reduced palmitoylation of HTT and other HIP14 substrates contributes to the pathogenesis of the disease. ... [more]
Hum. Mol. Genet. Aug. 01, 2014; 23(15);4142-60 [Pubmed: 24705354]
Throughput
- High Throughput
Curated By
- BioGRID