BAIT
PPARGC1A
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
GO Process (32)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- RNA splicing [TAS]
- androgen receptor signaling pathway [NAS]
- brown fat cell differentiation [TAS]
- cellular glucose homeostasis [NAS]
- cellular respiration [TAS]
- cellular response to oxidative stress [ISS]
- circadian regulation of gene expression [ISS]
- digestion [TAS]
- fatty acid oxidation [NAS]
- gluconeogenesis [NAS]
- mRNA processing [TAS]
- mitochondrion organization [NAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of neuron death [IGI]
- positive regulation of ATP biosynthetic process [ISS]
- positive regulation of energy homeostasis [ISS]
- positive regulation of fatty acid oxidation [TAS]
- positive regulation of gluconeogenesis [TAS]
- positive regulation of histone acetylation [TAS]
- positive regulation of mitochondrion organization [IBA, ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein complex assembly [TAS]
- protein stabilization [TAS]
- regulation of circadian rhythm [ISS]
- regulation of transcription, DNA-templated [IDA]
- respiratory electron transport chain [ISS]
- response to muscle activity [ISS]
- response to starvation [NAS]
- temperature homeostasis [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
RELA
NFKB3, p65
v-rel avian reticuloendotheliosis viral oncogene homolog A
GO Process (43)
GO Function (20)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular defense response [NAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to interleukin-1 [IDA]
- cellular response to interleukin-6 [IMP]
- cellular response to nicotine [IMP]
- cellular response to peptide hormone stimulus [IMP]
- cellular response to tumor necrosis factor [IDA]
- cytokine-mediated signaling pathway [IDA]
- defense response to virus [NAS]
- inflammatory response [IDA]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [IDA, TAS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of cell proliferation [IDA]
- positive regulation of miRNA metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of type I interferon production [TAS]
- regulation of inflammatory response [ISS]
- response to UV-B [IDA]
- response to interleukin-1 [IGI]
- response to organic substance [IDA]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- NF-kappaB binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- activating transcription factor binding [IPI]
- chromatin binding [IDA]
- identical protein binding [IDA, IPI]
- phosphate ion binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- DNA binding [IDA]
- NF-kappaB binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- activating transcription factor binding [IPI]
- chromatin binding [IDA]
- identical protein binding [IDA, IPI]
- phosphate ion binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP.
Binding of multiple myeloma (MM) cells to bone marrow stromal cells (BMSCs) triggers expression of adhesive molecules and secretion of interleukin-6 (IL-6), promoting MM cell growth, survival, drug resistance, and migration, which highlights the possibility of developing and validating novel anti-MM therapeutic strategies targeting MM cells-host BMSC interactions and their sequelae. Recently, we have found that expression of the peroxisome ... [more]
Blood Dec. 15, 2007; 110(13);4373-84 [Pubmed: 17785586]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Curated By
- BioGRID