OPRM1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- behavioral response to ethanol [IMP]
- cellular response to morphine [IBA]
- cellular response to stress [IMP]
- negative regulation of Wnt protein secretion [IMP]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of cAMP-mediated signaling [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of cytosolic calcium ion concentration [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- neuropeptide signaling pathway [IMP]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of neurogenesis [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- sensory perception [NAS]
- sensory perception of pain [IBA, ISS]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
COPS5
Gene Ontology Biological Process
- cullin deneddylation [IDA]
- exosomal secretion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein deneddylation [IMP]
- protein deubiquitination [IDA]
- regulation of JNK cascade [IDA]
- transcription from RNA polymerase II promoter [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.
The mu-opioid receptor (MOR) is the G-protein coupled receptor primarily responsible for mediating the analgesic and rewarding properties of opioid agonist drugs such as morphine, fentanyl, and heroin. We have utilized a combination of traditional and modified membrane yeast two-hybrid screening methods to identify a cohort of novel MOR interacting proteins (MORIPs). The interaction between the MOR and a subset ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OPRM1 COPS5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| OPRM1 COPS5 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| COPS5 OPRM1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID