OPRM1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IDA, ISO]
- adenylate cyclase-inhibiting opioid receptor signaling pathway [ISO]
- behavioral response to ethanol [ISO]
- calcium ion transmembrane transport [ISO]
- cellular response to morphine [IBA, ISO]
- cellular response to stress [IBA, ISO]
- locomotory behavior [IGI, IMP]
- negative regulation of Wnt protein secretion [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP-mediated signaling [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of nitric oxide biosynthetic process [ISO]
- neuropeptide signaling pathway [IBA, ISO]
- opioid receptor signaling pathway [IBA, ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of appetite [ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of neurogenesis [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of sensory perception of pain [ISO]
- response to ethanol [ISO]
- sensory perception of pain [IMP]
- synaptic transmission [IBA]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IBA, ISO]
- G-protein beta-subunit binding [IBA, ISO]
- G-protein coupled receptor activity [ISO]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [ISO]
- morphine receptor activity [IBA, ISO]
- neuropeptide binding [IBA]
- opioid receptor activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- voltage-gated calcium channel activity [ISO]
- G-protein alpha-subunit binding [IBA, ISO]
- G-protein beta-subunit binding [IBA, ISO]
- G-protein coupled receptor activity [ISO]
- beta-endorphin receptor activity [IBA, ISO]
- filamin binding [ISO]
- morphine receptor activity [IBA, ISO]
- neuropeptide binding [IBA]
- opioid receptor activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
VAPA
Gene Ontology Biological Process
- COPII-coated vesicle budding [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- cell death [ISO]
- negative regulation by host of viral genome replication [ISO]
- neuron projection development [ISO]
- positive regulation by host of viral genome replication [ISO]
- positive regulation by host of viral release from host cell [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- protein localization to endoplasmic reticulum [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens.
The mu-opioid receptor (MOR) is the G-protein coupled receptor primarily responsible for mediating the analgesic and rewarding properties of opioid agonist drugs such as morphine, fentanyl, and heroin. We have utilized a combination of traditional and modified membrane yeast two-hybrid screening methods to identify a cohort of novel MOR interacting proteins (MORIPs). The interaction between the MOR and a subset ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID