BAIT
HIST1H1C
H1.2, H1C, H1F2, H1s-1
histone cluster 1, H1c
GO Process (0)
GO Function (3)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WDR61
REC14, SKI8
WD repeat domain 61
GO Process (6)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- histone H3-K4 trimethylation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- positive regulation of histone H3-K4 methylation [IMP]
- positive regulation of histone H3-K79 methylation [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.
Increasing evidence suggests that linker histone H1 can influence distinct cellular processes by acting as a gene-specific regulator. However, the mechanistic basis underlying such H1 specificity and whether H1 acts in concert with other chromatin-altering activities remain unclear. Here, we show that one of the H1 subtypes, H1.2, stably interacts with Cul4A E3 ubiquitin ligase and PAF1 elongation complexes and ... [more]
Cell Rep Dec. 26, 2013; 5(6);1690-703 [Pubmed: 24360965]
Throughput
- High Throughput
Additional Notes
- MudPIT
Curated By
- BioGRID