BAIT
PI4K2A
Pi4k2
phosphatidylinositol 4-kinase type 2 alpha
GO Process (3)
GO Function (5)
GO Component (22)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BLOC-1 complex [ISO]
- cytoplasmic vesicle [ISO]
- dendrite [IDA]
- early endosome membrane [ISO]
- endosome [ISO]
- exocytic vesicle [ISO]
- growing cell tip [ISO]
- host cell presynaptic membrane [IDA]
- integral component of plasma membrane [ISO]
- intracellular membrane-bounded organelle [ISO]
- intrinsic component of membrane [ISO]
- lysosomal membrane [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrion [IDA]
- neuron projection [IDA, ISO]
- neuronal cell body [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- presynaptic membrane [IDA]
- protein complex [ISO]
- synaptic vesicle membrane [ISO]
Mus musculus
PREY
SH3GL2
CNSA2, EEN-B1, SH3D2A, SH3P4
SH3-domain GRB2-like 2
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- central nervous system development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.
Phosphatidylinositol (PI) 4-phosphate (PI(4)P) and its metabolizing enzymes serve important functions in cell signalling and membrane traffic. PI 4-kinase type IIα (PI4KIIα) regulates Wnt signalling, endosomal sorting of signalling receptors, and promotes adaptor protein recruitment to endosomes and the trans-Golgi network. Here we identify the E3 ubiquitin ligase Itch as binding partner and regulator of PI4KIIα function. Itch directly associates ... [more]
EMBO Rep. Dec. 01, 2012; 13(12);1087-94 [Pubmed: 23146885]
Throughput
- Low Throughput
Additional Notes
- Table S1
- association inhibited by ubiquitinated PI4KIIa
Curated By
- BioGRID