BAIT
LATS1
WARTS, wts
large tumor suppressor kinase 1
GO Process (11)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- cytoplasmic sequestering of protein [IMP]
- hippo signaling [IDA, TAS]
- hormone-mediated signaling pathway [ISS]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of actin filament polymerization [IDA]
- regulation of protein complex assembly [IMP]
- sister chromatid segregation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PABPN1
OPMD, PAB2, PABII, PABP-2, PABP2
poly(A) binding protein, nuclear 1
GO Process (13)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- RNA processing [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA 3'-end processing [TAS]
- mRNA splicing, via spliceosome [TAS]
- modification by virus of host mRNA processing [TAS]
- modulation by virus of host morphology or physiology [TAS]
- modulation by virus of host process [TAS]
- muscle contraction [TAS]
- poly(A)+ mRNA export from nucleus [IMP]
- termination of RNA polymerase II transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral life cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.
Proper regulation of cell proliferation, cell apoptosis, and cell death are vital for the development and survival of living organisms. Failure or dysfunction of any of these processes can have devastating effects, including cancer. The Hippo pathway, first discovered in Drosophila, has been found to be a major growth-regulatory signaling pathway that controls these crucial processes and has been implicated ... [more]
Cell Cycle Oct. 07, 2013; 12(24); [Pubmed: 24107629]
Throughput
- Low Throughput
Curated By
- BioGRID